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There are a lot of different ideas about what causes fibromyalgia. Most Defense Shield Pro Review people agree that the brain and spinal cord in fibromyalgia patients overreacts to pain, and this is called "central sensitization." An extensive research study by the Centers for Disease Control of patients with chronic fatigue syndrome, which is closely related to fibromyalgia, shows genetic differences in how people with fibromyalgia respond to stress. Imaging studies have shown abnormalities within parts of the brain that process pain in fibromyalgia patients.
Continued stress over a period of time, such as accidents, repeated infection, or emotional trauma, can result in the central nervous system continuing to send pain messages even after the original stress has stopped. Frequent muscle pain over a long time can cause changes to the central nervous system, which results in chronic, widespread pain.
Inflammation may also lead to central sensitization. Fibromyalgia patients don't have enough anti-inflammatory cytokines in their blood. Inflammation may activate nervous system cells called glial cells that cause the spinal cord to make pain messages, even after the original source of pain has gone away. Researchers have also been able to measure lower levels of neurotransmitters, chemicals that send messages to the brain, like dopamine, serotonin and norepinephrine in the spinal fluid of fibromyalgia patients.
Other differences have also been measured in spinal fluid, such as higher levels of inflammatory Substance P. It is clear that several health problems that cause pain or inflammation are related to fibromyalgia, such as whiplash, auto immune diseases, and psychological stress.